Savita Marmat* and H.S. Rathore

School of Studies in Zoology & Biotechnology Vikram University, Ujjain-456010 (India)

ABSTRACT

Study deals with involvement of hepatorenal damages in broiler chicks following paracetamol (acetaminophen) administration of lethal dose at 24 hr. Fourteen days old healthy, unsexed broiler chicks Gallus gallus domesticus were divided into two groups. Chicks of first group received single intramuscular injections of vehicle (Control-Gr.I) while chicks of another group received single i.m injections of paracetamol at 2gm/kg/bw; lethal dose at 24 hr. Next day freshly dissected liver and kidneys from both groups were washed, fixed, sectioned and stained for histological observations. Blood drawn directly from the heart was used for the estimations of the biochemical parameters. Observations of tissue slides revealed severe damage to hepatic and kidney tissues. Degenerative changes were main effects. Increased levels of transaminases (GOT & GPT), alkaline phosphatase, bilirubin , lowered protein and disturbed levels of electrolytes in the serum suggest impaired hepatorenal functions due to paracetamol toxicity. Observed results suggest that lethality of paracetamol in chicks also seems mainly due to severe oxidative damage to hepatorenal tissue as happens in human and experimental animals.

Key words : Broiler chicks, paracetamol, hepatorenal damage.

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