Emerging tuberculosis risks and natural flavonoids: A cross talk
1Sabina Begum Choudhury, 1Nazifa Sahani Barbhuiya, 1Rajat Nath, and *1,2Manabendra Dutta Choudhury
1Department of Life Science and Bioinformatics, Assam University, Silchar-788011 (India) 2Bioinformatics Centre (DBT-BIF), Assam University, Silchar-788011 (India) *Corresponding author, email: drmdc@bioinfoaus.ac.in
ABSTRACT
Flavonoids are a broad family of small molecular secondary metabolites that have the potential to act as antibiotic substitutes. Flavonoids have a wide structural diversity and show inhibitory activity against a variety of bacterial pathogens. Therefore, it stands out to be an ideal template for therapeutic development against a variety of chronic bacterial infections. There has always been a great demand for new drugs against many diseases among which tuberculosis may also be considered. Tuberculosis (TB) is the most common infectious cause of death worldwide. Several studies confirmed synergistic relationship between flavonoids and anti-microbial drugs. The goal of this work is to review the current tuberculosis research and development of flavonoids as prospective tuberculosis prevention drugs which may pave a new way for future tuberculosis treatment.