Shobha Shrivastava and Monika Bokde*

Department of Microbiology Govt. M.L.B. Girls (Auto.) College Bhopal-462 006 (India) *Corresponding author Mob. +919764003583 Email: monikabokde@gmail.com

ABSTRACT

The aqueous extract from the leaves of Aegle marmelos Corr. was investigated to evaluate its possible effects on the L-thyroxine (L-T4) induced hyperthyroidism and propylthiouracil induced hypothyroidism. While an alteration in serum T3 and T4 concentration was observed in L-Thyroxine (0.5mg/kg) and Propylthiouracil (10 mg/kg) treated animals, simultaneous administration of the plant extract at a dose of 250 mg/kg/ d (p.o.) for 15days in hyperthyroid mice reduced T3 and T4 concentrations by 78% and 54% respectively. But no effect was shown on the level of T3 and T4 in Propylthiouracil treated animals. These findings reveal that Aegle marmelos inhibits thyroid activity.

Key words : Aegle marmelos, Propylthiouracil, Thyroxine. Hypothyroidism, Hyperthyroidism

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