D. Veerakumar1 and M. Muthulingam*2

1,2Department of Zoology, Annamalai University, Annamalai Nagar-608 002 (India) *Author for Correspondence Dr. M. Muthulingam Email: muthuau@rediffmail.com Contact: +91 98436 29002


Plants have been considered as wellsprings of therapeutic specialists for the treatment of numerous sicknesses. The therapeutic potential of Asteracantha longifolia L. (Nees) was evaluated by thioacetamide induced fatty liver in rats. Male albino wistar rats were orally treated with Asteracantha longifolia (50, 100 and 200 mg/kg body weight) or silymarin (25 mg/kg) daily with administration of Thioacetamide (100 mg/kg body weight- s.c) only one day. Thioacetamide induced fatty liver and significantly increased the levels of total cholesterol, free fatty acids, triglycerides and phospholipids in kidney as compared with control group. Treatment with Asteracantha longifolia or silymarin successively for twenty eight days could notably decrease the levels of renal lipid profiles in kidney when compared with Thioacetamide only treated rats. Thus, our results indicate that the administration of 200 mg/ kg BW Asteracantha longifolia extract restores near normal lipid profile in thioacetamide-diabetic rats.

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