Toxicity assessment of single dose of leaf aqueous extract of Angelica archangelica L.
Pooja Sharma and Era Upadhyay*
Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur-3030022 (India) *era.upadhyay@gmail.com; 91-9772815346
ABSTRACT
Angelica archangelica L. is an extreme valued medicinal herb, cultivated in Norden, and exported to different parts of Europian countries. Treditionally, it is used as a vitalizing bronchial tonic. It is also used for digestion problem, basic debility, and persistent bronchitis. The fresh crushed leaves of the plant are applicable in poultices in lung and chronic chest diseases. It is basically a potent therapeutic drug so every part of this plant is a matter of concern. Thus, our aim is to establish safety of useful parts of this plant. We have assessed the oral acute toxicity as per OECD guideline 423 for 2000 mg kg-1 dose and observed behavioural, haematological and biochemical parameters on 14th days. After administration of single 2000 mg kg-1 dose of leaf aqueous extract of Angelica archangelica to albino wistar rat, not a single adverse symptom noticed related to behavioural, haematological and biochemical parameters. It is concluded that the dose of leaf aqueous extract of Angelica archangelica was found safe up to 2000 mg kg-1 in single dose in albino wistar rat.