Decalepis hamiltonii (Wight & Arn) roots as a hepatoprotectant against ethanol toxicity
*R. Harish and 1T. Shivanandappa
*Department of Studies in Microbiology, Pooja Bhagavat Memorial Mahajana Post Graduate Centre, Wing of SBRR Mahajana First Grade College, Mysuru-570016 (India) 1Department of Food Protectants and Infestation Control, Central Food Technological Research Institute, Mysuru-570020 (India) Corresponding author: harishrh@yahoo.com
ABSTRACT
The hepatoprotective efficacy of a methanolic extract of Decalepis hamiltonii (Wight & Arn) root extract against ethanol-induced hepatotoxcity in rats was investigated. Serum enzymes such as glutamate-pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were used to assess ethanol-induced hepatotoxicity. Glutathione peroxides (GPx), glutathione reductase (GR), glutathione transferase (GTS), catalase (CAT), and glutathione (GSH) were also measured in liver tissue. The results revealed an increase in serum enzymes and lipid peroxidation in the liver of the ethanol-treated group, as well as a decrease in antioxidant enzymes and GSH content in the liver. Pretreatment of extract (50-200m/kg body weight) prior ethanol administration restored the ethanol-induced alterations to normal levels. Histopathological examination further confirmed the protective effect. The findings of this investigation demonstrated that D. hamiltonii root extract protects against ethanol-induced hepatocellular damage.