Heavy metals as a risk factor for Parkinson’s disease: An epidemiological and insilico study
1Bhargawi Mishra, 2Sooraj Patil, 1Neha Srivastava, 1Abhishek Pathak, 3Geeta J. Gautam and 1V. N. Mishra
1Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005 (India) 2Chinmaya Mission Hospital, Bengaluru-560038 (India) 3Department of Zoology, Mahila Mahavidyalaya, Banaras Hindu University, Varanasi-221005 (India) Corresponding author: Prof. V.N. Mishra, Geeta J. Gautam
ABSTRACT
The exact cause of Parkinson’s disease is not known, but both genetic and environmental factors are thought to play a role in its development. Exposure to heavy details such as lead, manganese, cadmium, copper, iron, and mercury has been linked to an increased risk of Parkinson’s disease (PD). Our study aimed to find out the presence and concentration of lead (Pb), cadmium (Cd), and manganese (Mn) in the whole blood of PD patients and their age-match control group and find out the association of these metals with 48 Parkinson's disease patients and 47 healthy control people were screened for this study based on MRI report reading. The metal concentration was estimated in the blood sample after acid digestion and estimation was done via ICP MS technique. A patch dock tool was used for docking metals (Pb, Cd, and Mn) with targeted This study suggests that all three metals may contribute to the risk of PD. Further study is needed for mechanism of action of these heavy metals.