Chemical characterization and anti-proliferative potential of Hexene fraction of Sauromatum venosum (Dryand. ex Alton) Kunth
1Namrata Kahar, 2Megha Yadav, 2Renu Bhatt and 2Rohit Seth
1Department of Zoology, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur - 495009 (India) Email: namratakahar3@gmail.com 2Department of Forensics, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur - 495009 (India) Email: meghaforensics@gmail.com 2Department of Biotechnology, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur - 495009 (India) Email: rbhatt1996@yahoo.com 2Department of Zoology, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur - 495009 (India) Email: rohitseth123@gmail.com *Address for correspondence- Dr. Rohit Seth (Associate Professor)2 Email: rohitseth123@gmail.com, Department of Zoology, Guru Ghasidas Vishwavidyalaya, Koni, Bilaspur - 495009 (India)
ABSTRACT
The present study investigates the antioxidant, antiinflammatory, quantitative, anti-proliferation activity and spectral characterization of phytochemicals present in the Sauromatum venosum (SV) medicinal plant. The objective of the current study was to determine the phytoconstituents and their potential of Sauromatum venosum (SV) tuber by performing the antioxidant assay, and anti-inflammatory activity in the hexene fraction (eSV1) of extract. UV-Vis, FTIR analysis spectral characterization of phytochemicals showed the presence of carbohydrates, carboxylic acid, phenols, and flavonoids. The hexene fraction showed a dose-dependent manner of increasing antioxidant activity and in-vitro anti-inflammatory activity. The anti-proliferative activity at lower IC50 -98.59 ± 1.98 μg/ml was observed against prostate cancer cells (DU145). A considerable decrease (50 %) in cell proliferation. The results indicate that the hexene fraction of S. venosum tuber extract (eSV1) possesses significant potential to effectively neutralize oxidative radicals, with its efficacy varying according to dosage. This antioxidative capability is likely attributed to the presence of phytochemical constituents, suggesting their contribution to the anti-proliferation activity leading to pharmacological and antioxidant properties. Abbreviations : SV - Sauromatum venosum, ABTS- 2,2’azinobis (3-ethylbenz-thiazoline-6-sulphonic acid) diammonium salt, FTIR-Fourier transform infrared spectroscopy