Exploring the Antibacterial potential of novel 2-Aminophenyl- 2-(2,4,5-Triphenylimidazole) Acetate Derivatives: A comprehensive design and synthesis approach
Piyusha Kolhe, *Rahul K. Godge and Amol S. Dighe
Department of Pharmaceutical Chemistry, Pravara Rural College off Pharmacy Pravaranagar, Loni-413713 (India) *For Correspondence : Email: rahul.godge@pravara.in Mobile: +91-9561282059
ABSTRACT
Antibiotic resistance is a growing concern, and the development of new antibacterial agents is crucial. 2-aminophenyl-2-(2,4,5- triphenylimidazole) derivatives have shown potential as antibacterial agents in previous studies, and this study aims to further explore their potential. In this study, a series of 2-aminophenyl-2-(2,4,5- triphenylimidazole) derivatives were designed and synthesized. Their antibacterial activity was evaluated against Escherichia coli and Staphylococcus aureus using the disc diffusion method. The compounds were also evaluated for druglikeness and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) properties. Molecular docking studies were conducted to investigate the binding modes of the compounds with biotin protein ligase. The synthesized compounds exhibited varying degrees of antibacterial activity, with AC6 showing the highest activity against both E. coli and S. aureus. The compounds were found to adhere to Lipinski’s rule of five, indicating good druglikeness, and exhibited favourable ADMET properties. The molecular docking studies revealed that the compounds had favourable binding modes with biotin protein ligase (PDB ID: 4DQ2). The 2-aminophenyl-2- (2,4,5-triphenylimidazole) derivatives designed and synthesized in this study exhibited promising antibacterial activity against E. coli and S. aureus. The compounds also demonstrated good Druglikeness and favourable ADMET properties. The molecular docking studies provided insights into the binding modes of the compounds with biotin protein ligase. These results suggest that 2-aminophenyl-2-(2,4,5- triphenylimidazole) derivatives have potential as antibacterial agents and warrant further investigation.