Formulation and evaluation of herbal anti-diabetic capsule containig Trigonella foenum-graecum L. and Musa paradisiaca L.
1 Abubakar Bawazir and *2 Sumaiya Khan
1,*2Y.B Chavan College of Pharmacy, Aurangabad. 431001 (India) *2Corresponding author: Sumaiya Khan, e-mail id:ksumaiya40@gmail.com
ABSTRACT
Aim of current study to formulate and evaluate antidiabetic capsules containing Trigonella foenum-graecum L. fenugreek seeds and Musa paradisiaca L. raw banana. Both drugs were subjected to powder microscopic analysis. Fenugreek seeds were extracted with hydro-alcoholic solvent and raw banana fruits with peels were extracted with alcohol. Both the extracts were tested by phytochemicals tests, Quercetin in raw banana and diosgenine in fenugreek was identified by HPTLC fingerprint analysis,drug –drug and drug-excipient compatibility was studied using FT-IR. Preformulation study was performed on prepared granules; capsules were prepared and evaluated for weight variation, disintegration and in-vitro alpha amylase assay for antidiabetic activity. Both drugs showed the presence of phytochemicals like steroids, flavonoids, tannins, phenols, and saponins. HPTLC fingerprint analysis confirms the presence of quercetin and diosgenine in raw banana and fenugreek respectively. Both extracts and drug excipients were found to be compatible after the IR study. Capsules containing both extracts were found to have good alpha-amylase activity.From all the results it can be concluded that the current formulation presents significant challenges in terms of manufacturing and optimizing therapeutic outcomes because the actual quantities of phytochemicals in the extracts are not standardized.