Comparative Effectiveness of Plant Therapy versus Synergistic Activity and Antibiotics in Targeting Porphyromonas gingivalis
Ritika Lalwani1 and Vaishali Thool2
1Institute for Higher Learning, Research and Specialized Studies, Sardar Patel Mahavidyalaya, Chandrapur - 442401 (India) 2Department of Microbiology Sardar Patel Mahavidyalaya, Chandrapur - 442401 (India) Email address of corresponding author: ritikalalwani77@yahoo.in
ABSTRACT
Colonisation by periodontopathogen Porphyromonas gingivalis is commonlyreported with dental plaque. In recent time with increasing drug resistance; control of P. gingivalis is better achieved via ethnopharmacology where use of plant bio-actives with antibiotics is norm. In the present study P. gingivalis susceptibility towards Amoxycillin (30mcg), Ciprofloxacin (5mcg),Azithromycin (15mcg) and Tetracycline (10mcg) has been recorded along with MIC assay. The present resistance profile has been recorded and resistant drugs were tested in synergy with ethanolic extracts of Ginger, B. propolis, Amla, Eucalyptus, and Guava to record comparative change in sole effect and in synergy for better control of infection. In results 15 strains of P. gingivalis along with standard strain found to be sensitive towards Ciprofloxacin and Azithromycin and resistant toward Amoxicillin and Tetracycline in totality. Further, extracts of 25 plants recorded for growth inhibition and among them only five plants namelyGinger, B. propolis, Amla, Eucalyptus and Guava found to be promising antibacterial. Lastly, in synergy study only plant Amla (Phyllanthus emblica) with Tetracycline able to showcase better synergy based on significantly high (P<0.05) inhibition compared to plant extract and antibiotics sole inhibition data. Conclusively, the success of synergy of Amla (P. emblica) with Tetracycline controlling P. gingivalis strains was reported in a promising manner and only five plants can be used for better control of periodontitis.