Transethosomes: Revolutionizing transdermal drug delivery through innovative Formulation strategies
Manish Mohan Ghadage and Naina Dubey*
Department of Pharmaceutics,Acropolis Institute of Pharmaceutical Education and Research, Indore - 453771 (India) *Address for correspondence: Naina Dubey, Acropolis Institute of PharmaceuticalEducation and Research, Indore - 453771 (India) E-mail: nainadubey@acropolis.edu.in
ABSTRACT
In recent years, transdermal medication delivery has gained popularityfor circumventingoral administration challenges. Despite skin penetration difficulties, researchers have devised a solution by encapsulating medication into vesicles that penetrate deeper. Examples such as liposomes, niosomes, ethosomes, and transferosomes tend to aggregate within skin layers. Transethosomes, comprising phospholipids, ethanol, and an edge activator, have emerged as promising alternatives, effectively addressing issues like poor bioavailability and organ toxicity. They enhance skin penetration, facilitating the delivery of various medications including analgesics, proteins, corticosteroids, and anticancer agents. This review provides comprehensive insights into transethosomes, their applications, and preparation methods.