Formulation and evaluation of mouth dissolving oral film for Drooling
Dhanshri Kalsai*, Revan Karodi2, Sagar Gaikwad3 and Kunal Warvatkar4
M Pharmacy, Quality Assurance Techniques, Dr D.Y. Patil College OF Pharmacy, Akurdi Pune - 411044 (India) dhanashrikalsai@gmail.com 2Dr D.Y. Patil College of Pharmacy, Akurdi Pune - 411044 (India) Corresponding Author: - Dhanshri Kalsai Email: - dhanashrikalsai@gmail.com Mobile No: - 7776988365
ABSTRACT
Drooling also known as sialorrhea refers to unintentional loss of oral material from the mouth, such as saliva. The aim of this work was to develop a fast-acting mouth-dissolving benzhexol HCl thin film that would minimize drooling. It has a low oral bio availability and is a strong drooling regulator in children with cerebral palsy. Many people find it challenging to swallow conventional dosage forms such as capsules and tablets. A fast-dissolving oral film was developed to help with all of these issues and to increase the bio availability of medications. mouth films disintegrate quickly with medications, and the majority of medications enter the systemic circulation via the mouth mucosa. Oral films from the optimum batch dissolve in 20 seconds. Additional evaluations were conducted for the optimum film, including drug concentration, folding durability, pH values, disintegration duration, percentage elongation, and appearance.