Formulation, optimization and evaluation of niosomal suspension loaded with Cinnammomum zeylanicum and Zingiber officinale for allievating symptoms of PCOS
Riya Singh1* and Vaibhav Ravindra Vaidya2
1,2Department of Pharmaceutics, Dr. D.Y. Patil College of Pharmacy, Akurdi, Pune - 411044 India Corresponding Author- Riya Singh Mailing Address- Dr. D.Y. Patil College of Pharmacy. E-mail- singhriya.rs29@gmail.com Contact No- 7000197987
ABSTRACT
Often characterized by insulin resistance, hyperandrogenism, and chronic anovulation, Polycystic Ovary Syndrome (PCOS) is a common endocrine condition affecting women of reproductive age. Side effects and insufficient symptom alleviation are common problems with current treatments. The goal of this study is to reduce the symptoms of PCOS by formulating, optimizing, and testing a niosome suspension containing bioactive components from Zingiber officinale (ginger) and Cinnamomum zeylanicum (cinnamon). The ether injection approach was used to create niosomes, which improve the stabilityand bioavailability of medications enclosed. Several formulation parameters were methodically optimized, such as the kind of surfactant, the amount of cholesterol. The in vitro release kinetics, zeta potential, encapsulation efficiency, and particle size of the resultant niosome suspension were all measured. Niosome suspensions are significant because they have the ability to get around the drawbacks of traditional medication delivery methods. Therapeutic results can be improved by increasing the solubility, preventing degradation, and achieving a regulated release of bioactive chemicals byencasing them in niosomes. The potential of this method in controlling PCOS is further supported by the use of natural extracts, such as cinnamon and ginger, which are known to have anti- inflammatory, antioxidant, and insulin-sensitizing characteristics.