Niosomal in situ Nasal gel formulation of Doxepin HCL: A promising approach for Depression treatment
Pratik Katare1* and Pallavi M. Chaudhari2
1Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune - 411044 India pratikkatare2017@gmail.com 2Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune - 411044 India pallavichaudhari@dyppharmaakurdi.ac.in *Address for correspondence : Pratik Katare pratikkatare2017@gmail.com Dr. D.Y. Patil College of Pharmacy Akurdi Pune - 411044 India
ABSTRACT
This study majorly focuses on the formulation of the Doxepin HCL filled niosomal in-situ nasal gel for depression therapy. Doxepin HCL in situ nasal gel was created with the Ether injection method. The formulation was modified to increase the bio availability of the drug molecules. There are two barriers present in brain which are known as CSF barrier and BBB that produces hinderance to molecules to transport to the brain, but they allow lipophilic drug molecules to permeate. The particle size of optimized batch was found to be 422.75±110.65 nm. The entrapment efficiency of optimised formulation was found to be 88.89%. The niosomes were optimized by 23 factorials. And optimized batch of niosomes is incorporated into gel in 1:1 ratio. After eight hours of in-vitro release, the highest release was discovered to be 80.12%.