Study on phytochemical, antibacterial, antifungal, antioxidant and anticancer activity of Nerium oleander L.
Initha Lebanon Ebency. C1, Flory Shobana. M2 and Vanitha. N3
1Department of Microbiology, Annai Violet Arts and Science College, Chennai, Tamilnadu - 600053 {India} 2Department of Biotechnology, Hindusthan Arts & Science College, Coimbatore, Tamilnadu - 641028 {India} 3Department of Microbiology, Hindusthan Arts & Science College, Coimbatore, Tamilnadu– 641028 {India}
ABSTRACT
Plants have provided a source of inspiration for novel drug compounds as plants derived medicine have made significant contribution to human health. Phytomedicine can be used for the treatment of manydiseases. The objectives of this work are to investigate the phytochemical, antioxidant, antimicrobial and cytotoxic effects of the plant Nerium oleander floral extracts. These activities had been evaluated by DPPH, disk diffusion, and MTT assay respectively. The result of phytochemical analysis showed the presence of flavonoids, terpenoids, cardiac glycoside, saponins, phenolic compounds in different solvents. Acetone extract from Nerium oleander flower showed antimicrobial and antifungal activity. Free radical scavenging activities of the extracts was evaluated using DPPH method. The results showed that antioxidant activity97.78µg/ml respectively.Anticancer activitywas measure by MTT assay. Acetone extract showed significant toxicity to the triple negative breast cancer cell line {MDA-MB-231} at the dose level tested. The extract of Nerium oleander flower had significant antioxidant, antimicrobial and cytotoxic activity.