Evaluation of Anthelmintic potential of Curcuma aromatica Salisb., and Curcuma amada Roxb. fresh rhizomes
1*Marina G. D’souza, 1ChDivyasri, 1K. Ramesh, 1D. Suchithra, 1K. Sandhya, 2Vivek V. Byahatti, and 2*Laxmikant B. Borse
1*Department of Pharmacognosy, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra - 422213 (India) 1Bharat School of Pharmacy, Hyderabad-501510 (India) 2Department of Pharmacognosy, School of Pharmaceutical Sciences, Sandip University, Nashik, Maharashtra - 422213 (India) 2*Department of Pharmacology, Sandip Institute of Pharmaceutical Sciences, Nashik, Maharashtra - 422213 (India) *Corresponding author, E.mail: marina47abc@gmail.com
ABSTRACT
Helminth parasites infect nearly one-third of the global population, making them one of the most widespread infectious agents. Thisstudyevaluates the anthelmintic potential of rhizomes from Curcuma aromatica (Wild turmeric) and Curcuma amada (Mango ginger) against Indian earthworm (Pheretima posthuma) and Roundworm (Ascaris lumbricoides) used as screening models.Aqueous and ethanolic extracts of fresh rhizomes were tested at concentrations of 10 mg/ml, 20 mg/ml, and 40 mg/ml. The time to paralysis and death of the helminths was recorded and compared to standard piperazine citrate. The ethanolic extract of Curcuma amada at 40 mg/ml showed significant anthelmintic activity, inducing paralysis and death in Pheretima posthuma at 50.22 and 90,02 minutes, respectively, followed by Curcuma aromatica at 51.02 and 90.22 minutes. Ascaris lumbricoides presented paralysis at 46.02 min. and death at 80.22 min. in Curcuma amada followed by 47.22 min paralysis and death in 82.12 min comparable to the standard drug. These findings suggest that fresh rhizomes of Curcuma aromatica and Curcuma amada are promising natural alternatives for treating helminth infections in humans and animals