Enhanced Delivery of Sulfasalazine via Niosomal Gel: A New Horizon in Rheumatoid Arthritis Therapy
Mrunmayee M. Thombare1* and Vaibhav Vaidya2
1Department of pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044 (India) mrunmayeethombare1323@gmail.com 2Associate Professor at Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune-411044 (India) v.vaidya123@gmail.com *Corresponding Author: Email – mrunmayeethombare1323@gmail.com
ABSTRACT
The goal of this research is to create a novel sulfasalazine- loaded niosomes formulation for improved therapeutic efficacy in the management of rheumatoid arthritis. Niosomes vesicles were prepared using the dry ether injection procedure. Enhancing the medicines’ bioavailability and subsequently their regulated release from niosomal vesicles received particular focus. Two surfactants, span 60 and tween 80, were combined to improve the biocompatibility and trapping efficiency. To enhance the drug’s bioavailability, cholesterol acts as a hard membrane to regulate the pace of release and shield it from deterioration. Because the central composite design provides information about the effects of many variables on the responses, it was used for optimization. Design expert software was utilized to optimize and choose the optimal arrangement of cholesterol and surfactants were employed. Using design expert software, 13 batches of varying compositions were created. The final product was then created by combining the tailored niosomes with a gel foundation. Using a Franz diffusion cell, the produced niosomal gel was assessed for its physicochemical characteristics and drug release investigations. In comparison to traditional dosage forms, the results show that the sulfasalazine loaded niosomal gel had higher drug entrapment efficiency, sustained drug release profile, and enhanced skin penetration. After optimized batches were further examined using SEM and zeta potential, it was discovered that the medication was widely and uniformly distributed throughout the vesicles. Every outcome was appropriate and accurate. Overall, this study shows that niosomal gel has the potential to be a viable carrier system for better sulfasalazine administration, providing new perspectives for the treatment of inflammatorydisorders.