Development and assessment of Thiolated galactomannan from seeds of Caesalpinia pulcherrima as a film former in drug delivery
Harshal Sanjay Bhandari1* and Rajendra Dayaram Wagh1
1*, 1DCSs A R A College of Pharmacy, Nagaon, Dhule - 424005 [India] 1*Corresponding author: Harshal Sanjay Bhandari, Email id: harshalbhandari54@gmail.com
ABSTRACT
Objective: Objective of present investigations is isolation and thiolation of galactomannan from seeds of Caesalpinia pulcherrima by esterification method and evaluate for film forming ability of isolated and modified polysaccharide. Galactomannan from seeds Caesalpinia pulcherrima were isolated by aqueous maceration method and thiolated by using thioglycollic acid Thiolation of polysaccharide was estimated by using Ellman’s reagent. Zeta potential measurement, DSC thermogram, 1H NMR, and FT-IR were used to confirm the thiolation of Caesalpinia pulcherrima galactomannan. Film was casted by using isolated and modified seed galactomannan used for evaluation of film making potential for medication delivery. The results showed that thiolation of the isolated galactomannan significantly improved the film-making property. Chemically modified galactomannan was used to create a biodegradable film that showed enhanced mechanical, strength, folding endurance, drug release, and mucoadhesive properties. As a conclusion, it can be said that thiolated galactomannan from seeds of Caesalpinia pulcherrima is suitable film forming material for drug delivery system.