Evaluation of anticancer and antibacterial activity of crude protein extract from saltpan actinomycetes
V. Selvamania, and P. K. Senthilkumar*
a*Department of Microbiology, Faculty of science, Annamalai University, Chidambaram - 608002 [India]
ABSTRACT
Naturally occurring antibiotics and other bioactive compounds have been shown to be mostly derived from Streptomyces. Finding and identifying theactinomycetes exhibiting antagonistic activity was the primary the current investigation’s objective. Out of the 17 actinomycetes that were isolated and evaluated against four bacterial pathogens, a strain was identified from marine sand samples that were obtained off the Indian coast of the Kodiyakkarai region. It generated compounds that were effective against pathogens that are Gram positive and Gram negative. Shake flask conditions have been shown to maximize thenutritional needs and cultural conditions for the highest possible growth and yield of bioactive chemicals. Furthermore, research on the crude extract’s anticancer efficacy against the human breast cancer cell lineMDA-MB-231 was conducted. Nonetheless, in the future, the actinomycetes found in the marine ecosystem will be helpful in the search for novel medications.