Development of Nebivolol-β-Cyclodextrin-HPMC Ternary inclusion complex for enhancement of Solubility and Dissolution rate
1*Vinod S. Ahire and 1Vaibhavkumar A. Jagtap
Department of Pharmaceutics, A.R.A. College of Pharmacy, Dhule - 424005 (India) *1Corresponding author’s E-mail: vinod.ahire18@gmail.com
ABSTRACT
The present study was aimed to improve the solubility and dissolution rate of poorly soluble drug nebivolol through ternary inclusion complex using β-cyclodextrin and HPMC. Physical mixture and Binary inclusion complexes were prepared with varying drug to β-Cycodextrin molar ration (1:1, 1:2, 1:3 and 1:4) by kneading method. Binary inclusion complexes system showed multi fold increase in solubility of drugs compared to its native form. Binary complexes at molar ratio of 1:2 was further utilised for the formation of ternary inclusion complex using HPMC.