Aniline induced Liver and Spleen Toxicity in experimental Albino rat
1Pallavi Mohurle, 1Varsha Dhurvey, 2Rashmi Urkude and 3Ira Urkude
1Department of Zoology RTM Nagpur University, Nagpur-440033, MS India 2Department of Chemistry, Shivaji Science College, Nagpur-440012, MS India 3Maharashtra National Law University, Nagpur-441108, MS India pallavimohurle32@gmail.com, varshadhurvey@yahoo.com, rashmi_urkude@rediffmail.com,defector101@gmail.com
ABSTRACT
In the present study, the effects of aniline administration on albinorats were examined. The experiment was divided into four groups from which group I as control and group II, III, IV treated rats were administered daily dose of6 mg/kg bw, 18 mg/kg bw, and 36 mg/kg bw of aniline for duration of 21 days respectively. The findings revealed a notable inverse relationship between aniline dose and body weight, with higher doses corresponding to reduced body weight among treated rats. Conversely, liver and spleen weights showed a marked increase proportional to the aniline dose.Additionally, level of proteins was reduced, while cholesterol and level of SGOT and SGPT were increased in liver with increasing dose of aniline compared to group I control. These results indicate that aniline exposure leads to substantial changes in body weight, liver and spleen weights, and a series of dose-dependent biochemical alterations. This suggests that aniline toxicity has measurable impacts on both physiological and metabolic parameters in albino rats.