Development and evaluation of Solid-self-Microemulsifying Drug Delivery system of Gliclazide
Harshal Dilip Mahajan1*, Prashant Suresh Salunke1, Hemant Vinayak Deore1, Mayur Ashok Bagul1 and Tanvirahmad J. Shaikh1
1DCS’s A.R.A. College of Pharmacy, Nagaon, Dhule - 424005 India Corresponding Author Details Email Id:-h.d.mahajan@gmail.com Orchid Id:- https://orcid.org/0000-0002-6619-2151 Mobile No:-9028147539
ABSTRACT
The objective of Gliclazide’s self-microemulsifying drug delivery system SMEDDS was to address the issues of low solubility and bioavailability. The formulation strategy involved screening surfactants and co-surfactants for emulsification ability and choosing the oil phase based on saturated solubility experiments. Using a dilution approach, ternary phase diagrams were created to determine the self- emulsifying zone. Selected formulations were evaluated byParticle size, DSC, XRD, Transmission Electron microscopy, freeze thawing method, self-emulsification, precipitation and in-vitro release study. Silicon dioxide, magnesium alminometa silicate, microporous calcium silicate, and microcrystalline cellulose were used in the adsorption process to create SMEDDS, which were then tested for dissolution and disintegration. It was determined that the formulation with 40 mg of Gliclazide, 200 mg of Olive Oil, 550 mg of Tween 20, and 550 mg of Polyethylene Glycol was optimal. Up to 120 minutes, the improved SMEDDS showed 100 per cent in vitro drug release, which was substantially higher than that of the pure drug. The SMDDS formulations that passed the thermodynamic stability testing were determined to be stable.