Meta-analysis Review of Antioxidant efficacy in Epilepsy/Seizure management with an Ayurvedic Perspective
1Mrunal Makwana and 2Swapnil Raskar
*Department of Kaumarbhritya, Parul Institute of Ayurved, Parul University, Vadodara - 391760 (India)
ABSTRACT
Seizures are a prevalent neurological disorder often linked to oxidative stress, which exacerbates neuronal injury. Epilepsy is a neurological disorder characterized by recurrent, unprovoked seizures caused by abnormal electrical activity in the brain. These seizures can vary in type and severity, leading to symptoms such as convulsions, loss of consciousness, or unusual sensations.11 This meta-analysis evaluates the effectiveness of various antioxidants, including vitamins E and C, glutathione, and alpha-lipoic acid, on seizure frequency and severity. A total of 30 studies, encompassing approximately 2,500 participants, were analyzed. Results indicate that antioxidants, particularly vitamin E and glutathione, significantly reduce both seizure frequency and severity, suggesting their potential as adjunctive therapies in epilepsy management. Moreover, Ayurvedic practices, which emphasize balancing bodily systems (Tridoshas) through dietary modifications and herbal interventions, offer promising complementary approaches to managing epilepsy. Further research is warranted to establish optimal dosing and long-term effects.