A study on the impact of Honey on Obesity-related characteristics in Rats fed a High-fat diet
*1Om Guptesh Sugandhi, 2Girish Kumar Vyas and Nitin Nama3
1,2School of Pharmacy, Career Point University, Kota - 324005 (India) 3Lord Buddha College of Pharmacy, Ranpur, Kota - 325003 (India) Corresponding Author: Om Guptesh Sugandhi, PG Scholar, School of Pharmacy, Career Point University, Kota - 324005 (India)
ABSTRACT
This study investigates the impact of Pauttika honey, a type of honey classified in Ayurvedic texts as “heating” and fat-mobilizing, on obesity-related parameters in rats fed a high-fat diet. The research aims to bridge traditional knowledge with modern science by identifying the honey type, analysing its physicochemical and nutritional properties, and evaluating its therapeutic potential. Honey samples were collected from bamboo tree honeycombs, characterized through organoleptic, sensory, and advanced analytical techniques like FTIR and HPLC. Experimental evaluation involved the administration of Pauttika honey to high-fat diet-induced obese rats. Key parameters including blood glucose, lipid profile, liver and kidney function tests, and hormones such as leptin, resistin, and adiponectin were measured. Histopathological analysis of vital organs was also performed. Results showed significant improvement in metabolic and hormonal profiles, along with reduced weight gain and preserved organ histology in honeytreated rats. The study concludes that Pauttika honey possesses potent anti-obesity properties and can serve as a natural therapeutic agent. It calls for further clinical research to validate these effects in human populations and promote integration of traditional remedies into modern obesity management.