Cancer and the influence of DNA repair gene XRCC1 Polymorphism: A Review
Shagufta Zafar and Krishna Prakash*
Recombinant DNA Technology Laboratory, Department of Biotechnology, Central University of South Bihar, Panchanpur Road, Gaya - 824236 (India) Corresponding Author: Krishna Prakash* Department of Biotechnology, Central University of South Bihar, Panchanpur Road, Gaya - 824236 (India) Email : krishna@cub.ac.in
ABSTRACT
The XRCC1 (X-ray cross complement protein 1) polymorphism has been demonstrated to act as a scaffold for DNA repair that can be plays a role in the progression of a variety of cancers such as breast, lung, head and neck, cervical and others. This polymorphism participates in multiple repair pathways and facilitates base excision along with single strand break repair. They have many functional polymorphisms that may result directly from damage to deoxyribose or indirectly through common intermediates of base expression repair for the treatment of serious diseases such as cancer. It functions as an essential co-transporter for a number of other repair proteins, such as DNA ligase 3 (LIG3), aprataxin, and PNKP-like factor (APLF). When XRCC1 binds to highly specific areas, it helps coordinate specific repair process by recruiting additional enzyme. This allow XRCC1 to managewide range of issues that arise during repair or in other repair pathways with which it interfaces. Numerous studies with varying conclusions have examined the association between the prognosis of HNSCC and the XRCC1 Arg 399Gln genetic polymorphism. Therefore, the present study aims to review cancer diseases and the influence of XRCC1 polymorphism as well as the repair mechanisms within which these interactions function. Study mainly based on the published articles; which is explored by Scopus, web of science, PubMed international database and others. Numerous genetic models declared that there was no significant association with cancer risk between the XRCC1 Arg 399Gln polymorphism.