Evaluation of phytochemical constituents, antibacterial, antifungal, anti-inflammatory and antioxidant analysis of Solanum xanthocarpum Schrad and Wendl.
Madhurya Remalli1 , Aravindhan Ravi2*, Ramya Mahalingam3 , Sathya Kumar M4 , Magesh Karuppur Thiagarajan5 and Sivachandran Annamalai6
1,2,3,4,5,6Department of Oral Pathology and Microbiology, SRM Kattankulathur Dental College and Hospital, SRM Institute of Science and Technology, Chengalpattu-603203 (India) *Corresponding author Email: aravindr1@srmist.edu.in
ABSTRACT
Many organisms that are present in the oral cavity are not pathogenic. The pathogenicity of the microorganisms affects the host when the host is immunocompromised due to systemic disease or immunosuppressive medications. The pathogenicity usually manifests as an infection, which is treated using antimicrobial agents. There are many plants that can potentially act as antimicrobial agents. One of such plants is Solanum xanthocarpum. S. xanthocarpum is also known as Indian nightshade, from the Solanaceae family which known for its medicinal properties. Many tribes consider this plant a vegetable. In traditional medicine, this plant plays an important role in treating mankind. Since it has convincing medicinal benefits and is being used in traditional medicine, we chose to test the potentiality as anti-inflammatory agent, anti-mycotic, anti-oxidant, and the phytochemical assay of the S. xanthocarpum. The objective of this study was to assess anti-mycotic, anti-inflammatory, anti-oxidant, phytochemical and germicidal effects of the S. Xanthocarpum. The anti-fungal property was analyzed by using Kirby- Bauer on Sabourad Dextrose Agar (SDA) medium. Antiinflammatory activity had been analyzed by inhibiting protein denaturation using 5 different concentrations of the plant extract. Phytochemical assay was done using 10 solutions. Anti-bacterial test was done by agar disc diffusion method using 4 different microorganisms at 3 different concentrations. The study proved that S. xanthocarpum can be used as a potential germicidal, anti-mycotic, anti-oxidant, antiinflammatory agent.