Solubility and Dissolution enhancement of Carbamazepine by Melt-Sono-Crystallization Technique
Chaitali Khemchand Gunjal1 , Jyotsna Pandit Khedkar2 , Snehal Jagan Takate2 , Niket S. Kankariya3 , Renuka subhash Hazare2 , Salva Midat3 and Sumitra Mane3
1Department of Pharmaceutics Shri Gulabrao Devkar College of Pharmacy, Shri Gulabrao Deokar College of Pharmacy, Mohadi Shivar, Shirsoli Road, Jalgaon - 425001 (India) 2Department of Pharmaceutics, Gangamai College of Pharmacy Nagaon, Dhule 424002 (India) 3Department of Pharmaceutics, Government College of Pharmacy Osmanpura, Aurangabad, 431005 (India) Corresponding Mail: bkjyotsna108@gmail.com
ABSTRACT
The present work aimed at the Solubility and Dissolution Enhancement of Carbamazepine by Melt-Sono-Crystallization Technique. Immediate Release Tablet was successfully prepared by Melt Sono crystallization Technique into different ratios. The Prepare ratio was evaluated according to the selected conditions. The successful preparations were compared with raw tablets as well as with marketed tablets in these selected conditions. The 32 factorial design was Performed by Selecting Gelucire 48/16 and Sonication Time As the independent variable and %DR as the Dependent Variable. The optimized formulation shows a %DR of 80.72% & 90.23% in the selected Conditions. Based on Evaluation the drug release of the F9 batch with sonication showed a release of 80.72% in water and 90.23% in HCL in 40 mins. Compared to the F3 batch without sonication showed 69.70 % in water and 75.17% in HCL. Solubility And Dissolution Enhancement of Carbamazepine by Melt-Sono-Crystallization Technique Was done successfully