Gastroretentive floating Bilayer Drug Delivery System-A Review
V. T. Iswariya1 , Haripriya Batchan2 and T. Rama Rao3
1-3Department of Pharmaceutics, CMR College of Pharmacy, Medchal, Hyderabad - 501401 (India) Corresponding Author V. T. Iswariya, E mail: iswariyapharma@gmail.com
ABSTRACT
In order to effectively treat inflammatory bowel syndrome, the current effort focuses on developing a bilayer floating system and bilayer gastroretentive floating tablets that provide site-specific administration, controlled drug release, and prolonged stomach retention. By minimizing fluctuations in the drug’s blood concentration, these drug delivery systems have been developed to mitigate the shortcomings of conventional drug administration techniques, including gastric retention, hence lowering undesirable toxicity and inefficiency. Gastroretentive drug delivery systems, which are mostly used to treat inflammatory bowel illnesses, extend the time that dose forms remain in the stomach or upper gastrointestinal tract in order to improve the bioavailability and therapeutic efficacy of drugs. Any drug’s bioavailability following oral delivery is influenced by how long it stays in the stomach. Drugs having a limited absorption window, reduced stability at high alkaline pH, and improved solubility at low pH.