Preparation and characterization of phytosomes containing extracted catechin for hepatoprotective activity
Himani Shendre, Abhilasha Singh and Aashish Manigaunha
Mittal Institute of Pharmacy, Navi Bagh, Karond, Bhopal, Madhya Pradesh 462038 (India) Corresponding authors email address: himanishendre8@gmail.com
ABSTRACT
Catechin, a bioflavonoid with anti-inflammatory, antioxidant, antitumor, and hepatoprotective properties, shows limited clinical potential due to poor gastrointestinal absorption, rapid metabolism, and low bioavailability. This study aims to enhance catechin’s therapeutic efficacy by formulating and characterizing catechin-loaded phytosomes. Phytosomes, formed by complexing bioactive compounds with phospholipids, improve membrane permeability, cellular uptake, and sustained drug release, making them suitable for hepatoprotective delivery. Catechin will be extracted from natural sources and encapsulated into phytosomes, which will be evaluated using analytical methods such as particle size analysis to confirm complex formation and optimize formulation for stability and high entrapment efficiency