Enhanced Wound Healing Efficacy of Calotropis gigantea (L.) Dryand. against Citrobacter Carbepenem Resistant MDR STRAIN by Ethanolic Extract: Molecular Mechanism elucidation through In vivo Validation and Nano-Formulation Development
S. Soundarapandian1* and R. Manju2
1,2Department of Microbiology, Hindusthan College of Arts and Science, Hindusthan Gardens, Avanashi Road, Odayamapalayam, Coimbatore, Tamil Nadu 641028 (India) Email : spkocai1987@ gmil.com 2PG and Research Department of Microbiology, Hindusthan College of Arts and Science, Hindusthan Gardens, Avanashi Road, Odayamapalayam, Coimbatore,Tamil Nadu 641028 (India) 2Email : rajumanju1985@gmail.com
ABSTRACT
More than one century after the traditional use of Calotropis gigantea in wound management was definitively established, nevertheless, the molecular mechanisms that support the therapeutic effects of the genus and optimising the system used for their delivery are poorly demonstrated hindering the clinical translation of this plant. To address critical knowledge gaps, this investigation is set to bridge considered biochemical knowledge gaps in wound healing mechanisms through in vivo, in terms of hydroxyproline and hexosamine quantification, and engineering nanoscale-enhanced topical formulation to supplement bioavailability