Hepatotoxic effects of Cyclophosphamide : A Mini Review
1Shalini Bharti, 2Varsha Dhurvey, 3Aashikkumar Nagwanshi and 4Dharita Joshi
1-4Department of Zoology, RTM Nagpur University, Nagpur - 440033 (India)
ABSTRACT
Cyclophosphamide is among the most successful chemotherapeutic drugs, still widely used over 50 years. It is a synthetic nitrogen mustard alkylating agent from the oxazaphosphorine group. It is used in treatment of various cancers (breast, ovarian, neuroblastoma, retinoblastoma) and autoimmune diseases, and is used as an immunosuppressant in transplantation. Although cyclophosphamide (CP) is an effective anticancer drug, it has several adverse effects, including genital disorders, testicular damage, cardiotoxicity, nephrotoxicity, and hepatotoxicity. Therefore, the present review aims to provide a comprehensive analysis of the hepatotoxic effects of this widely used cyclophosphamide.