Hepatotoxic effects of Tartrazine: A Mini Review
1Shweta Dhule, 2Varsha Dhurvey, 3Aashikkumar Nagwanshi and 4Pallavi Mohurle
1-4Department of Zoology, RTM Nagpur University, Nagpur-440033 (India)
ABSTRACT
Tartrazine is a synthetic yellow azo dye widely used as a food colouring agent to enhance colour and consumer appeal. Although it is permitted for use within acceptable daily intake limits, several studies have reported adverse effects associated with its consumption. The present review focuses on the hepatotoxic effects of tartrazine, highlighting changes in biochemical parameters, oxidative stress, and liver tissue architecture. Experimental evidence indicates that tartrazine induces liver damage in a dose- and duration-dependent manner, primarily through oxidative stress–mediated mechanisms. This review aims to increase awareness regarding the potential health risks of tartrazine and emphasizes the need for cautious use and safer alternatives.