A conceptual analysis and systematic literature review on the role of Chavyadi Churna in Alcohol use disorder associated anxiety
1J Navajyoth, 2Sariput N Bhosikar and 3Lekshmi C S
1,2Department of Agada Tantra Evam Vidhi Vaidyaka, Parul Institute of Ayurved and Research, Vadodara - 391760 (India) drnavajyothjayachandran@gmail.com 2drbsariput@gmail.com 3Department of Rasa Shastra and Bhaishajya Kalpana, Institute of Teaching and Research in Ayurveda, INI, GOI, Ministry of Ayush, Jamnagar - 361008 (India)
ABSTRACT
Alcohol dependence is a significant global health concern, leading to substantial morbidity and mortality. Anxiety disorders commonly coexist with Alcohol Use Disorder (AUD), increasing the risk of relapse. Conventional treatments prioritize abstinence but often overlook AUD-related anxiety. This study explores the potential of Chavyadi Churna, an Ayurvedic herbal formulation from Bhela Samhita, as an anxiolytic remedy for AUD-induced anxiety. A systematic literature review was conducted following PRISMA 2020 guidelines. Studies were sourced from PubMed, Scopus, and Google Scholar, focusing on the anxiolytic properties of herbal formulations in the context of alcohol dependence. Only peer-reviewed studies from the last decade were included. A conceptual analysis was performed using an empirical development approach. The research evaluated the bioactive components of Chavyadi Churna and their pharmacological effects on anxiety related to AUD. Findings were synthesized using AMSTAR criteria to ensure a high standard of evidence synthesis. Modern pharmacological treatments for AUD-associated anxiety primarily target serotonin reuptake and GABAergic modulation. Chavyadi Churna comprises herbs such as Piper chaba Trel. and Yunck, Ferula asafoetida L, Citrus medical. Zingiber officinale Roscoe, and Apium graveolens L. known for their neuroprotective and calming effects.